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HLA Disease associations

Olerup SSP kits for the screening of HLA-alleles associated with diseases.

There are autoimmune conditions with a strong association with HLAs, such as: Ankylosing Spondylitis associated to HLA-B*27; Narcolepsy a neurological disease closely associated with the HLA-DQB1*06:02 and over 95% of patients with Coeliac Disease have some isoform of HLA-DQ2 or DQ8.

Drug hypersensitivity: Abacavir is a nucleoside reverse transcriptase inhibitor used in conjunction with other antiretroviral agents in the treatment of HIV infection. Hypersensitivity to abacavir is immunologically mediated, driven by conventional MHC-I antigen presentation and activation of HLA-B*57:01.

All kits are available in 2 formats: with and without Taq Polymerase. All master mixes contain cresol red, glycerin , PCR buffer and dNTPs.

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